The present work reports for the first time the construction of a transgenic mouse strain with
specific expression of Cre recombinase in the kidney proximal tubule. A Cre/loxP strategy
was developed using sglt2 promoter to drive Cre recombinase expression in transgenic
mice. The mouse sglt2 5′ region consisting of the first exon, the first intron, and part of the
second exon was cloned upstream of a nucleotide sequence encoding the Cre
recombinase. Transgenic mice were generated by pronuclear injection, and tissue …