[HTML][HTML] Downregulation of liver X receptor-α in mouse kidney and HK-2 proximal tubular cells by LPS and cytokines
Y Wang, AH Moser, JK Shigenaga, C Grunfeld… - Journal of lipid …, 2005 - ASBMB
The acute-phase response (APR) suppresses type II nuclear hormone receptors and alters
the expression of their target genes involved in lipid metabolism in the liver and heart.
Therefore, we examined the expression of liver X receptor/retinoid X receptor (LXR/RXR)
and their target genes in kidney from mice treated with lipopolysaccharide (LPS) and in
human proximal tubular HK-2 cells treated with interleukin-1β (IL-1β) and tumor necrosis
factor-α (TNF-α). We found that LXRα and RXRα expression was suppressed by LPS in …
the expression of their target genes involved in lipid metabolism in the liver and heart.
Therefore, we examined the expression of liver X receptor/retinoid X receptor (LXR/RXR)
and their target genes in kidney from mice treated with lipopolysaccharide (LPS) and in
human proximal tubular HK-2 cells treated with interleukin-1β (IL-1β) and tumor necrosis
factor-α (TNF-α). We found that LXRα and RXRα expression was suppressed by LPS in …