Expression of hypoxia-inducible factor-1α and-2α in hypoxic and ischemic rat kidneys

C Rosenberger, S Mandriota, JS Ju… - Journal of the …, 2002 - journals.lww.com
Oxygen tensions in the kidney are heterogeneous, and their changes presumably play an
important role in renal physiologic and pathophysiologic processes. A family of hypoxia-
inducible transcription factors (HIF) have been identified as mediators of transcriptional
responses to hypoxia, which include the regulation of erythropoietin, metabolic adaptation,
vascular tone, and neoangiogenesis. In vitro, the oxygen-regulated subunits HIF-1α and-2α
are expressed in inverse relationship to oxygen tensions in every cell line investigated to …