Signaling at the slit diaphragm
T Benzing - Journal of the American Society of Nephrology, 2004 - journals.lww.com
Diseases of the glomerular filter of the kidney are a leading cause of end-stage renal failure.
Recent studies have emphasized the critical role of the slit diaphragm of podocytes for the
size-selective filtration barrier of the kidney and revealed novel aspects of the mechanisms
that lead to proteinuria, in both inherited and acquired diseases (1–4). Several critical
structural protein components of the slit diaphragm have been identified. Recently, it has
been speculated that these slit diaphragm proteins, in addition to their structural functions …
Recent studies have emphasized the critical role of the slit diaphragm of podocytes for the
size-selective filtration barrier of the kidney and revealed novel aspects of the mechanisms
that lead to proteinuria, in both inherited and acquired diseases (1–4). Several critical
structural protein components of the slit diaphragm have been identified. Recently, it has
been speculated that these slit diaphragm proteins, in addition to their structural functions …