[HTML][HTML] MKK6/3 and p38 MAPK pathway activation is not necessary for insulin-induced glucose uptake but regulates glucose transporter expression
M Fujishiro, Y Gotoh, H Katagiri, H Sakoda… - Journal of Biological …, 2001 - ASBMB
p38 mitogen-activated protein kinase (MAPK), which is situated downstream of MAPK
kinase (MKK) 6 and MKK3, is activated by mitogenic or stress-inducing stimuli, as well as by
insulin. To clarify the role of the MKK6/3-p38 MAPK pathway in the regulation of glucose
transport, dominant negative p38 MAPK and MKK6 mutants and constitutively active MKK6
and MKK3 mutants were overexpressed in 3T3-L1 adipocytes and L6 myotubes using an
adenovirus-mediated transfection procedure. Constitutively active MKK6/3 mutants up …
kinase (MKK) 6 and MKK3, is activated by mitogenic or stress-inducing stimuli, as well as by
insulin. To clarify the role of the MKK6/3-p38 MAPK pathway in the regulation of glucose
transport, dominant negative p38 MAPK and MKK6 mutants and constitutively active MKK6
and MKK3 mutants were overexpressed in 3T3-L1 adipocytes and L6 myotubes using an
adenovirus-mediated transfection procedure. Constitutively active MKK6/3 mutants up …