[HTML][HTML] Glucose stimulates Ca2+ influx and insulin secretion in 2-week-old β-cells lacking ATP-sensitive K+ channels
A Szollosi, M Nenquin, L Aguilar-Bryan, J Bryan… - Journal of Biological …, 2007 - ASBMB
In adult β-cells glucose-induced insulin secretion involves two mechanisms (a) a K ATP
channel-dependent Ca 2+ influx and rise of cytosolic [Ca 2+] c and (b) a K ATP channel-
independent amplification of secretion without further increase of [Ca 2+] c. Mice lacking the
high affinity sulfonylurea receptor (Sur1KO), and thus K ATP channels, have been
developed as a model of congenital hyperinsulinism. Here, we compared [Ca 2+] c and
insulin secretion in overnight cultured islets from 2-week-old normal and Sur1KO mice …
channel-dependent Ca 2+ influx and rise of cytosolic [Ca 2+] c and (b) a K ATP channel-
independent amplification of secretion without further increase of [Ca 2+] c. Mice lacking the
high affinity sulfonylurea receptor (Sur1KO), and thus K ATP channels, have been
developed as a model of congenital hyperinsulinism. Here, we compared [Ca 2+] c and
insulin secretion in overnight cultured islets from 2-week-old normal and Sur1KO mice …