Background: The brain plays a crucial role in the decision to eat, integrating multiple
hormonal and neural signals. A key factor controlling food intake is selective satiety, ie, the
phenomenon that the motivation to eat more of a food decreases more than does the
motivation to eat foods not eaten. Objective: We investigated the effect of satiation with
chocolate on the brain activation associated with chocolate taste in men and women.
Design: Twelve men and 12 women participated. Subjects fasted overnight and were …