Transmembrane activator and calcium modulator and cyclophilin ligand interactor enhances CD40-driven plasma cell differentiation
E Castigli, SA Wilson, A Elkhal, E Ozcan… - Journal of Allergy and …, 2007 - Elsevier
BACKGROUND: Transmembrane activator and calcium modulator and cyclophilin ligand
interactor (TACI) is a receptor used by B cell–activating factor of the TNF family and a
proliferation-inducing ligand (APRIL) to induce isotype switching independently of CD40
and is mutated in patients with common variable immunodeficiency. OBJECTIVE: We sought
to determine whether TACI and CD40 cooperate in inducing class switch recombination and
immunoglobulin production. METHODS: Naive mouse B cells were stimulated with …
interactor (TACI) is a receptor used by B cell–activating factor of the TNF family and a
proliferation-inducing ligand (APRIL) to induce isotype switching independently of CD40
and is mutated in patients with common variable immunodeficiency. OBJECTIVE: We sought
to determine whether TACI and CD40 cooperate in inducing class switch recombination and
immunoglobulin production. METHODS: Naive mouse B cells were stimulated with …