[HTML][HTML] Dendritic cells, BAFF, and APRIL: innate players in adaptive antibody responses
ICM MacLennan, CG Vinuesa - Immunity, 2002 - cell.com
ICM MacLennan, CG Vinuesa
Immunity, 2002•cell.comThe first antibody produced in bacterial or viral infection results from B cell growth as
plasmablasts. Dendritic cell-derived TNF-family ligands APRIL and/or BAFF enhance
plasmablast survival and differentiation to plasma cells. Expression of these ligands by
dendritic cells is promoted by innate immune signals that can convert subliminal B cell
activation to a productive response. While this may be lifesaving in the face of infection, it
can predispose to autoantibody production.
plasmablasts. Dendritic cell-derived TNF-family ligands APRIL and/or BAFF enhance
plasmablast survival and differentiation to plasma cells. Expression of these ligands by
dendritic cells is promoted by innate immune signals that can convert subliminal B cell
activation to a productive response. While this may be lifesaving in the face of infection, it
can predispose to autoantibody production.
Abstract
The first antibody produced in bacterial or viral infection results from B cell growth as plasmablasts. Dendritic cell-derived TNF-family ligands APRIL and/or BAFF enhance plasmablast survival and differentiation to plasma cells. Expression of these ligands by dendritic cells is promoted by innate immune signals that can convert subliminal B cell activation to a productive response. While this may be lifesaving in the face of infection, it can predispose to autoantibody production.
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