[HTML][HTML] Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?
W Kriz, B Kaissling, M Le Hir - The Journal of clinical …, 2011 - Am Soc Clin Investig
W Kriz, B Kaissling, M Le Hir
The Journal of clinical investigation, 2011•Am Soc Clin InvestigEpithelial-mesenchymal transition (EMT) has become widely accepted as a mechanism by
which injured renal tubular cells transform into mesenchymal cells that contribute to the
development of fibrosis in chronic renal failure. However, an increasing number of studies
raise doubts about the existence of this process in vivo. Herein, we review and summarize
both sides of this debate, but it is our view that unequivocal evidence supporting EMT as an
in vivo process in kidney fibrosis is lacking.
which injured renal tubular cells transform into mesenchymal cells that contribute to the
development of fibrosis in chronic renal failure. However, an increasing number of studies
raise doubts about the existence of this process in vivo. Herein, we review and summarize
both sides of this debate, but it is our view that unequivocal evidence supporting EMT as an
in vivo process in kidney fibrosis is lacking.
Epithelial-mesenchymal transition (EMT) has become widely accepted as a mechanism by which injured renal tubular cells transform into mesenchymal cells that contribute to the development of fibrosis in chronic renal failure. However, an increasing number of studies raise doubts about the existence of this process in vivo. Herein, we review and summarize both sides of this debate, but it is our view that unequivocal evidence supporting EMT as an in vivo process in kidney fibrosis is lacking.
The Journal of Clinical Investigation