Effect of resveratrol on 3-nitropropionic acid-induced biochemical and behavioural changes: possible neuroprotective mechanisms
P Kumar, SSV Padi, PS Naidu… - Behavioural …, 2006 - journals.lww.com
Huntington's disease is a progressive, degenerative disease characterized by abnormal
body movements called chorea, and a reduction of various mental abilities. 3-Nitropropionic
acid, an inhibitor of complex II of the electron transport chain, causes Huntington's disease-
like symptoms in rodents. Recently, it has been reported that oxidative stress, which is one of
the pathological hallmarks of various neurodegenerative disorders, also plays an important
role in the pathogenesis of Huntington's disease. The present study was designed to …
body movements called chorea, and a reduction of various mental abilities. 3-Nitropropionic
acid, an inhibitor of complex II of the electron transport chain, causes Huntington's disease-
like symptoms in rodents. Recently, it has been reported that oxidative stress, which is one of
the pathological hallmarks of various neurodegenerative disorders, also plays an important
role in the pathogenesis of Huntington's disease. The present study was designed to …