A chimeric VIP-PACAP analogue but not VIP pseudopeptides function as VIP receptor antagonists
VA Fishbein, DH Coy, SJ Hocart, NY Jiang… - Peptides, 1994 - Elsevier
The ability to assess the importance of VIP in different physiological processes is limited by
the lack of specific potent antagonists. In the present study, we have adopted two different
approaches used successfully with other peptides in an attempt to identify new VIP receptor
antagonists. One involves the formation of pseudopeptides by insertion of reduced peptide
bonds in the NH 2-terminus from position 2 to 8 of VIP. The other methodology involves the
formation of a COOH-terminal chimeric analogue by combining VIP (6–28) and PACAP (28 …
the lack of specific potent antagonists. In the present study, we have adopted two different
approaches used successfully with other peptides in an attempt to identify new VIP receptor
antagonists. One involves the formation of pseudopeptides by insertion of reduced peptide
bonds in the NH 2-terminus from position 2 to 8 of VIP. The other methodology involves the
formation of a COOH-terminal chimeric analogue by combining VIP (6–28) and PACAP (28 …