Release of vasoactive intestinal polypeptide in mast cells by histamine liberators
E Cutz, W Chan, NS Track, A GOTH, SI SAID - Nature, 1978 - nature.com
E Cutz, W Chan, NS Track, A GOTH, SI SAID
Nature, 1978•nature.comAbstract VASOACTIVE INTESTINAL POLYPEPTIDE (VIP), originally isolated from porcine
duodenum1, is a potent relaxant of vascular and nonvascular smooth muscle2, and a
stimulant of adenylate cyclase activity3, 4. The peptide has been localised in endocrine cells
in the gastrointestinal tract and pancreatic islets5, 6, as well as in nervous structures in these
and other organs7–9, the peripheral autonomic nervous system and selected areas of the
brain8–11. We report here immunological evidence that VIP, or a closely related peptide …
duodenum1, is a potent relaxant of vascular and nonvascular smooth muscle2, and a
stimulant of adenylate cyclase activity3, 4. The peptide has been localised in endocrine cells
in the gastrointestinal tract and pancreatic islets5, 6, as well as in nervous structures in these
and other organs7–9, the peripheral autonomic nervous system and selected areas of the
brain8–11. We report here immunological evidence that VIP, or a closely related peptide …
Abstract
VASOACTIVE INTESTINAL POLYPEPTIDE (VIP), originally isolated from porcine duodenum1, is a potent relaxant of vascular and nonvascular smooth muscle2, and a stimulant of adenylate cyclase activity3,4. The peptide has been localised in endocrine cells in the gastrointestinal tract and pancreatic islets5,6, as well as in nervous structures in these and other organs7–9, the peripheral autonomic nervous system and selected areas of the brain8–11. We report here immunological evidence that VIP, or a closely related peptide, occurs in mast cells, from which it can be released by compound 48/80 or by the Ca2+ ionophore A23187.
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