Helodermin has a VIP-like effect upon canine blood flow
S Naruse, A Yasui, S Kishida, M Kadowaki, M Hoshino… - Peptides, 1986 - Elsevier
The effect of helodermin on vascular physiology was studied in anesthetized dogs using a
synthetic replicate of helodermin and helodermin related peptides. Intraarterial infusion of
helodermin caused a dosedependent increase in femoral blood flow. Helodermin was 16
times less potent than VIP and 5 times more potent than PHM (human PHI). The helodermin
effect lasted significantly longer; the half-life of the helodermin effect was 6.5 times longer
than VIP. Synthetic helodermin (Hd) N-terminal fragment Hd (1–27) NH 2 retained …
synthetic replicate of helodermin and helodermin related peptides. Intraarterial infusion of
helodermin caused a dosedependent increase in femoral blood flow. Helodermin was 16
times less potent than VIP and 5 times more potent than PHM (human PHI). The helodermin
effect lasted significantly longer; the half-life of the helodermin effect was 6.5 times longer
than VIP. Synthetic helodermin (Hd) N-terminal fragment Hd (1–27) NH 2 retained …