BAFF induces a hyper-IgA syndrome in the intestinal lamina propria concomitant with IgA deposition in the kidney independent of LIGHT
DD McCarthy, S Chiu, Y Gao, LE Summers-deLuca… - Cellular …, 2006 - Elsevier
BAFF is a peripheral B cell survival factor and can mediate antibody (Ab) class switching.
Over-expression of BAFF in mice results in B cell hyperplasia, elevated serum
immunoglobulin (Ig), spontaneous germinal centre (GC) reactions and mild
glomerulonephritis (GN). Here we show that, in addition to driving excessive levels of serum
IgA, BAFF over-expression results in increased IgA levels within the intestinal lamina propria
(LP) and deposition of IgA immune complexes in the renal glomerular mesangium. LIGHT …
Over-expression of BAFF in mice results in B cell hyperplasia, elevated serum
immunoglobulin (Ig), spontaneous germinal centre (GC) reactions and mild
glomerulonephritis (GN). Here we show that, in addition to driving excessive levels of serum
IgA, BAFF over-expression results in increased IgA levels within the intestinal lamina propria
(LP) and deposition of IgA immune complexes in the renal glomerular mesangium. LIGHT …