[HTML][HTML] Smad3 differentially regulates the induction of regulatory and inflammatory T cell differentiation
Transforming growth factor β (TGF-β) is a crucial cytokine with pleiotropic functions on
immune cells. In CD4+ T cells, TGF-β is required for induction of both regulatory T and Th17
cells. However, the molecular mechanism underlying this differential T cell fate decision
remains unclear. In this study, we have evaluated the role of Smad3 in the development of
Th17 and regulatory T cells. Smad3 was found to be dispensable for natural regulatory T cell
function. However, induction of Foxp3 expression by TGF-β in naive T cells was significantly …
immune cells. In CD4+ T cells, TGF-β is required for induction of both regulatory T and Th17
cells. However, the molecular mechanism underlying this differential T cell fate decision
remains unclear. In this study, we have evaluated the role of Smad3 in the development of
Th17 and regulatory T cells. Smad3 was found to be dispensable for natural regulatory T cell
function. However, induction of Foxp3 expression by TGF-β in naive T cells was significantly …