Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus

GT Belz, CM Smith, L Kleinert… - Proceedings of the …, 2004 - National Acad Sciences
GT Belz, CM Smith, L Kleinert, P Reading, A Brooks, K Shortman, FR Carbone, WR Heath
Proceedings of the National Academy of Sciences, 2004National Acad Sciences
During lung infection with virus, airway-derived dendritic cells (DC) have been thought to be
the dominant cell type involved in acquisition, transport, and direct antigen presentation for
cytotoxic T lymphocyte priming. Contrary to this view, we have found that both an airway-
derived CD8α–CD11b–DC subset and distinct CD8α+ lymph node resident DC can present
class I-restricted antigens after lung infection with influenza virus or herpes simplex virus 1.
Presentation by a nonairway-derived DC population argues that cytotoxic T lymphocyte …
During lung infection with virus, airway-derived dendritic cells (DC) have been thought to be the dominant cell type involved in acquisition, transport, and direct antigen presentation for cytotoxic T lymphocyte priming. Contrary to this view, we have found that both an airway-derived CD8αCD11b DC subset and distinct CD8α+ lymph node resident DC can present class I-restricted antigens after lung infection with influenza virus or herpes simplex virus 1. Presentation by a nonairway-derived DC population argues that cytotoxic T lymphocyte priming may involve interplay between different DC subsets, not all of which originate within the site of infection.
National Acad Sciences