Mycobacterial granulomas: keys to a long-lasting host–pathogen relationship
DO Co, LH Hogan, SI Kim, M Sandor - Clinical Immunology, 2004 - Elsevier
Chronic infection with mycobacteria is controlled by the formation of granulomas. The failure
of granuloma maintenance results in reactivation of disease. Macrophages are the dominant
cell type in granulomas, but CD4+ T cells are the master organizers of granuloma structure
and function. Recent work points to an unrecognized role for nonspecific T cells in
maintaining granuloma function in the chronic phase of infection. In addition, it has become
clear that mycobacteria and host T cells collaborate in formation of granulomas. Further …
of granuloma maintenance results in reactivation of disease. Macrophages are the dominant
cell type in granulomas, but CD4+ T cells are the master organizers of granuloma structure
and function. Recent work points to an unrecognized role for nonspecific T cells in
maintaining granuloma function in the chronic phase of infection. In addition, it has become
clear that mycobacteria and host T cells collaborate in formation of granulomas. Further …