For adoptive T-cell therapy to be effective against solid tumors, tumor-specific T cells must
be able to migrate to the tumor site. One requirement for efficient migration is that the effector
cells express chemokine receptors that match the chemokines produced either by tumor or
tumor-associated cells. In this study, we investigated whether the tumor trafficking of
activated T cells (ATCs) bearing a chimeric antigen receptor specific for the tumor antigen
GD2 (GD2-CAR) could be enhanced by forced coexpression of the chemokine receptor …