[HTML][HTML] The functional role of the ELR motif in CXC chemokine-mediated angiogenesis
RM Strieter, PJ Polverini, SL Kunkel… - Journal of Biological …, 1995 - ASBMB
In this study, we demonstrate that the CXC family of chemokines displays disparate
angiogenic activity depending upon the presence or absence of the ELR motif. CXC
chemokines containing the ELR motif (ELR-CXC chemokines) were found to be potent
angiogenic factors, inducing both in vitro endothelial chemotaxis and in vivo corneal
neovascularization. In contrast, the CXC chemokines lacking the ELR motif, platelet factor 4,
interferon γ-inducible protein 10, and monokine induced by γ-interferon, not only failed to …
angiogenic activity depending upon the presence or absence of the ELR motif. CXC
chemokines containing the ELR motif (ELR-CXC chemokines) were found to be potent
angiogenic factors, inducing both in vitro endothelial chemotaxis and in vivo corneal
neovascularization. In contrast, the CXC chemokines lacking the ELR motif, platelet factor 4,
interferon γ-inducible protein 10, and monokine induced by γ-interferon, not only failed to …