Correlation of TGF beta 1 overexpression with down-regulation of proliferation-inducing molecules in HPV-11 transformed human tissue xenografts.
MK Shier, EB Neely, MG Ward, ME Richards… - Anticancer …, 1999 - europepmc.org
MK Shier, EB Neely, MG Ward, ME Richards, EC Manders, C Meyers, MK Howett
Anticancer research, 1999•europepmc.orgThe epidemiologic association of human papillomavirus (HPV) infection with dysplasia and
cervical cancer is well established. Transforming growth factor beta 1 (TGF beta 1) has
regulatory effects on a broad spectrum of cell types and is a growth inhibitory protein for
epithelial cells. To examine the phenotype of experimentally generated, HPV-11
transformed human tissues, we looked at expression of TGF beta 1 and a number of
proliferation-enhancing molecules which are known to be regulated by TGF beta 1 …
cervical cancer is well established. Transforming growth factor beta 1 (TGF beta 1) has
regulatory effects on a broad spectrum of cell types and is a growth inhibitory protein for
epithelial cells. To examine the phenotype of experimentally generated, HPV-11
transformed human tissues, we looked at expression of TGF beta 1 and a number of
proliferation-enhancing molecules which are known to be regulated by TGF beta 1 …
The epidemiologic association of human papillomavirus (HPV) infection with dysplasia and cervical cancer is well established. Transforming growth factor beta 1 (TGF beta 1) has regulatory effects on a broad spectrum of cell types and is a growth inhibitory protein for epithelial cells. To examine the phenotype of experimentally generated, HPV-11 transformed human tissues, we looked at expression of TGF beta 1 and a number of proliferation-enhancing molecules which are known to be regulated by TGF beta 1, including bcl-2, c-myc, c-Ha-ras, c-jun and NFkB. HPV-11 transformed xenografts showed up-regulation of TGF beta 1 expression and down-regulation of the expression levels of bcl-2, c-myc, c-Ha-ras, c-jun and NFkB. These results suggest that TGF beta 1 may exert antiproliferative effects on HPV-11 transformed papillomas by down-regulating different proliferation-enhancing molecules.
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