[HTML][HTML] Identification of a common protein association region in the neuronal Cdk5 activator
Cyclin-dependent protein kinase 5 (Cdk5) depends on the association with neuronal Cdk5
activator (Nck5a) for kinase activity. A variety of cellular proteins have been shown to
undergo high affinity association with Nck5a, including three novel proteins, C42, C48, and
C53 found by a yeast two-hybrid screen (Ching, YP, Qi, Z., and Wang, JH (2000) Gene 242,
285–294). The three proteins show competitive binding to Nck5a suggesting that they bind
at a common site. The binding site has been mapped to a region of 26 amino acid residues …
activator (Nck5a) for kinase activity. A variety of cellular proteins have been shown to
undergo high affinity association with Nck5a, including three novel proteins, C42, C48, and
C53 found by a yeast two-hybrid screen (Ching, YP, Qi, Z., and Wang, JH (2000) Gene 242,
285–294). The three proteins show competitive binding to Nck5a suggesting that they bind
at a common site. The binding site has been mapped to a region of 26 amino acid residues …