Peptidoglycan N-Acetylglucosamine Deacetylase, a Putative Virulence Factor in Streptococcus pneumoniae
Many glucosamine residues of the pneumococcal peptidoglycan (PG) are not acetylated,
which makes the PG resistant to lysozyme. A capsular type III mutant with an inactivated
pgdA gene (encoding the peptidoglycan N-acetylglucosamine deacetylase A) became
hypersensitive to exogenous lysozyme and showed reduced virulence in the intraperitoneal
mouse model.
which makes the PG resistant to lysozyme. A capsular type III mutant with an inactivated
pgdA gene (encoding the peptidoglycan N-acetylglucosamine deacetylase A) became
hypersensitive to exogenous lysozyme and showed reduced virulence in the intraperitoneal
mouse model.
Abstract
Many glucosamine residues of the pneumococcal peptidoglycan (PG) are not acetylated, which makes the PG resistant to lysozyme. A capsular type III mutant with an inactivated pgdA gene (encoding the peptidoglycan N-acetylglucosamine deacetylase A) became hypersensitive to exogenous lysozyme and showed reduced virulence in the intraperitoneal mouse model.
American Society for Microbiology