Sequence analysis of peptides bound to MHC class II molecules
AY Rudensky, P Preston-Hurlburt, SC Hong, A Barlow… - Nature, 1991 - nature.com
AY Rudensky, P Preston-Hurlburt, SC Hong, A Barlow, CA Janeway Jr
Nature, 1991•nature.comCD4 T cells recognize peptide fragments of foreign proteins bound to self class II molecules
of the major histocompatibility complex (MHC). Naturally processed peptide fragments
bound to MHC class II molecules are peptides of 13–17 amino acids which appear to be
precessively truncated from the carboxy terminus, perhaps after binding to the MHC class II
molecule. The finding of predominant self peptides has interesting implications for antigen
processing and self–non-self discrimination.
of the major histocompatibility complex (MHC). Naturally processed peptide fragments
bound to MHC class II molecules are peptides of 13–17 amino acids which appear to be
precessively truncated from the carboxy terminus, perhaps after binding to the MHC class II
molecule. The finding of predominant self peptides has interesting implications for antigen
processing and self–non-self discrimination.
Abstract
CD4 T cells recognize peptide fragments of foreign proteins bound to self class II molecules of the major histocompatibility complex (MHC). Naturally processed peptide fragments bound to MHC class II molecules are peptides of 13–17 amino acids which appear to be precessively truncated from the carboxy terminus, perhaps after binding to the MHC class II molecule. The finding of predominant self peptides has interesting implications for antigen processing and self–non-self discrimination.
nature.com