Graft versus host disease
LY Matsuoka - Journal of the American Academy of Dermatology, 1981 - Elsevier
Graft versus host disease (GVHD) occurs in 50% to 70% of patients receiving bone marrow
transplants. It can also develop in immunosuppressed patients with malignancies who
receive nonirradiated blood transfusions. Most work indicates that the primary mechanism of
GVHD is cell-mediated. It is likely that humoral factors are involved as well. Cutaneous
manifestations are the earliest and most frequent sign of the disease. These may be
morbilliform, scarlatiniform, lichenoid, or sclerodermoid lesions. In acute GVHD, the skin …
transplants. It can also develop in immunosuppressed patients with malignancies who
receive nonirradiated blood transfusions. Most work indicates that the primary mechanism of
GVHD is cell-mediated. It is likely that humoral factors are involved as well. Cutaneous
manifestations are the earliest and most frequent sign of the disease. These may be
morbilliform, scarlatiniform, lichenoid, or sclerodermoid lesions. In acute GVHD, the skin …