[HTML][HTML] Protective role of thrombin activatable fibrinolysis inhibitor in obstructive nephropathy‐associated tubulointerstitial fibrosis
Background: Thrombin‐activatable fibrinolysis inhibitor (TAFI) has been reported to affect
wound healing and fibrotic processes, but its role in renal tubulointerstitial fibrosis remains
unknown. Objective: To study its potential role, we compared TAFI‐deficient and wild‐type
mice for the degree of renal fibrosis caused by unilateral ureteral obstruction (UUO).
Methods: The grade of tubulointerstitial fibrosis, the activity of plasmin, MMP‐2 and MMP‐9
were evaluated on days 4 and 9 after UUO. Results: The renal content of hydroxyproline and …
wound healing and fibrotic processes, but its role in renal tubulointerstitial fibrosis remains
unknown. Objective: To study its potential role, we compared TAFI‐deficient and wild‐type
mice for the degree of renal fibrosis caused by unilateral ureteral obstruction (UUO).
Methods: The grade of tubulointerstitial fibrosis, the activity of plasmin, MMP‐2 and MMP‐9
were evaluated on days 4 and 9 after UUO. Results: The renal content of hydroxyproline and …