Human IRGM induces autophagy to eliminate intracellular mycobacteria
SB Singh, AS Davis, GA Taylor, V Deretic - Science, 2006 - science.org
SB Singh, AS Davis, GA Taylor, V Deretic
Science, 2006•science.orgImmunity-related p47 guanosine triphosphatases (IRG) play a role in defense against
intracellular pathogens. We found that the murine Irgm1 (LRG-47) guanosine triphosphatase
induced autophagy and generated large autolysosomal organelles as a mechanism for the
elimination of intracellular Mycobacterium tuberculosis. We also identified a function for a
human IRG protein in the control of intracellular pathogens and report that the human Irgm1
ortholog, IRGM, plays a role in autophagy and in the reduction of intracellular bacillary load.
intracellular pathogens. We found that the murine Irgm1 (LRG-47) guanosine triphosphatase
induced autophagy and generated large autolysosomal organelles as a mechanism for the
elimination of intracellular Mycobacterium tuberculosis. We also identified a function for a
human IRG protein in the control of intracellular pathogens and report that the human Irgm1
ortholog, IRGM, plays a role in autophagy and in the reduction of intracellular bacillary load.
Immunity-related p47 guanosine triphosphatases (IRG) play a role in defense against intracellular pathogens. We found that the murine Irgm1 (LRG-47) guanosine triphosphatase induced autophagy and generated large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. We also identified a function for a human IRG protein in the control of intracellular pathogens and report that the human Irgm1 ortholog, IRGM, plays a role in autophagy and in the reduction of intracellular bacillary load.
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