Adenovirus-mediated gene transfer of a secreted decoy human macrophage scavenger receptor (SR-AI) in LDL receptor knock-out mice
J Jalkanen, P Leppänen, O Närvänen, DR Greaves… - Atherosclerosis, 2003 - Elsevier
Macrophage scavenger receptors (MSR) play an important role in the pathogenesis of
atherosclerosis. Therefore, modulation of MSR activity could have a beneficial effect on
atherogenesis. One way to antagonize the function of a cell surface scavenger receptor is to
use a soluble decoy receptor. We have constructed a soluble, chimaeric fusion protein that
consists of the bovine growth hormone signal sequence and the human MSR AI
extracellular domains. This secreted decoy MSR (sMSR) was cloned into an adenoviral …
atherosclerosis. Therefore, modulation of MSR activity could have a beneficial effect on
atherogenesis. One way to antagonize the function of a cell surface scavenger receptor is to
use a soluble decoy receptor. We have constructed a soluble, chimaeric fusion protein that
consists of the bovine growth hormone signal sequence and the human MSR AI
extracellular domains. This secreted decoy MSR (sMSR) was cloned into an adenoviral …