Collagens are functional, high affinity ligands for the inhibitory immune receptor LAIR-1

RJ Lebbink, T de Ruiter, J Adelmeijer… - The Journal of …, 2006 - rupress.org
RJ Lebbink, T de Ruiter, J Adelmeijer, AB Brenkman, JM van Helvoort, M Koch…
The Journal of experimental medicine, 2006rupress.org
Collagens are the most abundant proteins in the human body, important in maintenance of
tissue structure and hemostasis. Here we report that collagens are high affinity ligands for
the broadly expressed inhibitory leukocyte-associated immunoglobulin-like receptor-1 (LAIR-
1). The interaction is dependent on the conserved Gly-Pro-Hyp collagen repeats. Antibody
cross-linking of LAIR-1 is known to inhibit immune cell function in vitro. We now show that
collagens are functional ligands for LAIR-1 and directly inhibit immune cell activation in vitro …
Collagens are the most abundant proteins in the human body, important in maintenance of tissue structure and hemostasis. Here we report that collagens are high affinity ligands for the broadly expressed inhibitory leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1). The interaction is dependent on the conserved Gly-Pro-Hyp collagen repeats. Antibody cross-linking of LAIR-1 is known to inhibit immune cell function in vitro. We now show that collagens are functional ligands for LAIR-1 and directly inhibit immune cell activation in vitro. Thus far, all documented ligands for immune inhibitory receptors are membrane molecules, implying a regulatory role in cell–cell interaction. Our data reveal a novel mechanism of peripheral immune regulation by inhibitory immune receptors binding to extracellular matrix collagens.
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