[HTML][HTML] The role of collagen in thrombosis and hemostasis
RW Farndale, JJ Sixma, MJ Barnes… - Journal of Thrombosis and …, 2004 - Elsevier
Collagens represent up to 40% of the total protein of the vessel wall, forming an insoluble
scaffold which is essential for tissue integrity and which provides a surface for the
attachment of other matrix constituents and for the adhesion of vascular cells. Thus
collagens exercise important regulatory functions within the vasculature. At least 25 different
types of collagen exist [1], a number of which, including major, widely distributed types I, III,
IV, V and VI, occur in the vessel wall [2]. Three polypeptide chains (α-chains) form the …
scaffold which is essential for tissue integrity and which provides a surface for the
attachment of other matrix constituents and for the adhesion of vascular cells. Thus
collagens exercise important regulatory functions within the vasculature. At least 25 different
types of collagen exist [1], a number of which, including major, widely distributed types I, III,
IV, V and VI, occur in the vessel wall [2]. Three polypeptide chains (α-chains) form the …