[HTML][HTML] The prognostic value of natural killer cell infiltration in resected pulmonary adenocarcinoma
I Takanami, K Takeuchi, M Giga - The Journal of thoracic and …, 2001 - Elsevier
I Takanami, K Takeuchi, M Giga
The Journal of thoracic and cardiovascular surgery, 2001•ElsevierObjective: Natural cytotoxicity caused by mediated natural killer cells is believed to play an
important role in host-cancer defense mechanisms. Immunohistochemically, we have
detected natural killer cells in tissue specimens from patients with pulmonary
adenocarcinoma and have assessed their clinical characteristics. Methods: Using the
monoclonal antibody for CD57 specific marker for natural killer cells, we quantified natural
killer cell infiltration in 150 patients with pulmonary adenocarcinoma who underwent …
important role in host-cancer defense mechanisms. Immunohistochemically, we have
detected natural killer cells in tissue specimens from patients with pulmonary
adenocarcinoma and have assessed their clinical characteristics. Methods: Using the
monoclonal antibody for CD57 specific marker for natural killer cells, we quantified natural
killer cell infiltration in 150 patients with pulmonary adenocarcinoma who underwent …
Objective
Natural cytotoxicity caused by mediated natural killer cells is believed to play an important role in host-cancer defense mechanisms. Immunohistochemically, we have detected natural killer cells in tissue specimens from patients with pulmonary adenocarcinoma and have assessed their clinical characteristics.
Methods
Using the monoclonal antibody for CD57 specific marker for natural killer cells, we quantified natural killer cell infiltration in 150 patients with pulmonary adenocarcinoma who underwent curative tumor resection to investigate the relationship between natural killer cell counts and clinicopathologic factors and prognosis.
Results
The natural killer cell count was significantly related to the regulation of tumor progression, involving T classification, N classification, and stage (P = .01 for T classification or stage; P = .02 for N classification). A significant difference in the rate of patient survival was detected between those patients whose tumors had either high or low natural killer cell counts in both the overall and stage I groups (P = .0002 for the overall group; P = .049 for the stage I group).
Conclusion
These data indicate that natural killer infiltration may contribute to the regulation of tumor progression and that the natural killer cell count can serve as a useful prognostic marker in overall and stage I pulmonary adenocarcinoma. (J Thorac Cardiovasc Surg 2001;121:1058-63)
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