Glutamate and schizophrenia: phencyclidine, N‐methyl‐d‐aspartate receptors, and dopamine–glutamate interactions
DC Javitt - International review of neurobiology, 2007 - Elsevier
Schizophrenia is a serious mental disorder that affects up to 1% of the population worldwide.
As of yet, neurochemical mechanisms underlying schizophrenia remain unknown. To date,
the most widely considered neurochemical hypothesis of schizophrenia is the dopamine
hypothesis, which postulates that symptoms of schizophrenia may result from excess
dopaminergic neurotransmission particularly in striatal brain regions, along with
dopaminergic deficits in prefrontal brain regions. Alternative neurochemical models of …
As of yet, neurochemical mechanisms underlying schizophrenia remain unknown. To date,
the most widely considered neurochemical hypothesis of schizophrenia is the dopamine
hypothesis, which postulates that symptoms of schizophrenia may result from excess
dopaminergic neurotransmission particularly in striatal brain regions, along with
dopaminergic deficits in prefrontal brain regions. Alternative neurochemical models of …