Identification of promoter sequences in the 5'untranslated region of the baboon apolipoprotein [a] gene
JE Hixson, C Jett, S Birnbaum - Journal of lipid research, 1996 - ASBMB
Like humans, baboons possess apolipoprotein [a](apo [a]), a unique protein component of
the atherogenic lipoprotein [a](Lp [a]) particle. Baboon apo [a] also exhibits extensive
variation with respect to size and serum levels. In this report, we have cloned the 5'flanking
region of the baboon apo [a] gene (I isoform) and performed promoter mapping studies to
identify sequences that control apo [a] transcription. The sequence of the baboon apo [a]
5'flanking region is similar to the human gene, and contains two Alu repeats that distinguish …
the atherogenic lipoprotein [a](Lp [a]) particle. Baboon apo [a] also exhibits extensive
variation with respect to size and serum levels. In this report, we have cloned the 5'flanking
region of the baboon apo [a] gene (I isoform) and performed promoter mapping studies to
identify sequences that control apo [a] transcription. The sequence of the baboon apo [a]
5'flanking region is similar to the human gene, and contains two Alu repeats that distinguish …