Apelin: a new plasma marker of cardiopulmonary disease

JP Goetze, JF Rehfeld, J Carlsen, R Videbaek… - Regulatory peptides, 2006 - Elsevier
OBJECTIVES: Dyspnea is a major symptom of both parenchymal lung disease and chronic
heart failure. Underlying cardiac dysfunction can be assessed by measurement of cardiac-
derived B-type natriuretic peptide or its precursor in plasma. However, no specific endocrine
marker of the lung parenchyma has so far been identified. We therefore examined whether
plasma concentrations of apelin, a novel inotropic hormone, is affected in patients with
chronic parenchymal lung disease without cardiac dysfunction. METHODS AND RESULTS …