[HTML][HTML] Chronic Mycobacterium abscessus infection and lung function decline in cystic fibrosis
CR Esther Jr, DA Esserman, P Gilligan, A Kerr… - Journal of Cystic …, 2010 - Elsevier
CR Esther Jr, DA Esserman, P Gilligan, A Kerr, PG Noone
Journal of Cystic Fibrosis, 2010•ElsevierBACKGROUND: Although nontuberculous mycobacteria (NTM) are recognized pathogens
in cystic fibrosis (CF), associations with clinical outcomes remain unclear. METHODS:
Microbiological data was obtained from 1216 CF patients over 8years
(481±55patients/year). Relationships to clinical outcomes were examined in the subset (n=
271, 203±23 patients/year) with longitudinal data. RESULTS: Five hundred thirty-six of 4862
(11%) acid-fast bacilli (AFB) cultures grew NTM, with Mycobacterium abscessus (n= 298 …
in cystic fibrosis (CF), associations with clinical outcomes remain unclear. METHODS:
Microbiological data was obtained from 1216 CF patients over 8years
(481±55patients/year). Relationships to clinical outcomes were examined in the subset (n=
271, 203±23 patients/year) with longitudinal data. RESULTS: Five hundred thirty-six of 4862
(11%) acid-fast bacilli (AFB) cultures grew NTM, with Mycobacterium abscessus (n= 298 …
BACKGROUND
Although nontuberculous mycobacteria (NTM) are recognized pathogens in cystic fibrosis (CF), associations with clinical outcomes remain unclear.
METHODS
Microbiological data was obtained from 1216 CF patients over 8years (481±55patients/year). Relationships to clinical outcomes were examined in the subset (n=271, 203±23 patients/year) with longitudinal data.
RESULTS
Five hundred thirty-six of 4862 (11%) acid-fast bacilli (AFB) cultures grew NTM, with Mycobacterium abscessus (n=298, 55.6%) and Mycobacterium avium complex (n=190, 35.4%) most common. Associated bacterial cultures grew Stenotrophomonas or Aspergillus species more often when NTM were isolated (18.2% vs. 8.4% and 13.9% vs. 7.2%, respectively, p<0.01). After controlling for confounders, patients with chronic M. abscessus infection had greater rates of lung function decline than those with no NTM infection (−2.52 vs. −1.64% predicted FEV1/year, p<0.05).
CONCLUSIONS
NTM infection is common in CF and associated with particular pathogens. Chronic M. abscessus infection is associated with increased lung function decline.
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