[HTML][HTML] RhoA/Rho kinase up-regulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis
The small G-protein RhoA regulates the actin cytoskeleton, and its involvement in cell
proliferation has also been established. In contrast, little is known about whether RhoA
participates in cell survival or apoptosis. In cardiomyocytes in vitro, RhoA induces
hypertrophic cell growth and gene expression. In vivo, however, RhoA expression leads to
development of heart failure (Sah, VP, Minamisawa, S., Tam, SP, Wu, TH, Dorn, GW, Ross,
J. Jr., Chien, KR, and Brown, JH (1999) J. Clin. Investig. 103, 1627–1634), a condition …
proliferation has also been established. In contrast, little is known about whether RhoA
participates in cell survival or apoptosis. In cardiomyocytes in vitro, RhoA induces
hypertrophic cell growth and gene expression. In vivo, however, RhoA expression leads to
development of heart failure (Sah, VP, Minamisawa, S., Tam, SP, Wu, TH, Dorn, GW, Ross,
J. Jr., Chien, KR, and Brown, JH (1999) J. Clin. Investig. 103, 1627–1634), a condition …