[HTML][HTML] Genetic loss of calcineurin blocks mechanical overload-induced skeletal muscle fiber type switching but not hypertrophy
SA Parsons, DP Millay, BJ Wilkins, OF Bueno… - Journal of Biological …, 2004 - ASBMB
The serine/threonine phosphatase calcineurin is an important regulator of calcium-activated
intracellular responses in eukaryotic cells. In higher eukaryotes, calcium/calmodulin-
mediated activation of calcineurin facilitates direct dephosphorylation and nuclear
translocation of the transcription factor nuclear factor of activated T-cells (NFAT). Recently,
controversy has surrounded the role of calcineurin in mediating skeletal muscle cell
hypertrophy. Here we examined the ability of calcineurin-deficient mice to undergo skeletal …
intracellular responses in eukaryotic cells. In higher eukaryotes, calcium/calmodulin-
mediated activation of calcineurin facilitates direct dephosphorylation and nuclear
translocation of the transcription factor nuclear factor of activated T-cells (NFAT). Recently,
controversy has surrounded the role of calcineurin in mediating skeletal muscle cell
hypertrophy. Here we examined the ability of calcineurin-deficient mice to undergo skeletal …