[HTML][HTML] G protein-coupled receptor-mediated phosphorylation of the activation loop of protein kinase D: dependence on plasma membrane translocation and protein …
O Rey, JR Reeve, E Zhukova, J Sinnett-Smith… - Journal of Biological …, 2004 - ASBMB
Protein kinase D (PKD) is a serine/threonine protein kinase activated by G protein-coupled
receptor (GPCR) agonists through an incompletely characterized mechanism that includes
its reversible plasma membrane translocation and activation loop phosphorylation via a
protein kinase C (PKC)-dependent pathway. To gain a better understanding of the
mechanism regulating the activation of PKD in response to GPCR stimulation, we
investigated the role of its rapid plasma membrane translocation on its activation loop …
receptor (GPCR) agonists through an incompletely characterized mechanism that includes
its reversible plasma membrane translocation and activation loop phosphorylation via a
protein kinase C (PKC)-dependent pathway. To gain a better understanding of the
mechanism regulating the activation of PKD in response to GPCR stimulation, we
investigated the role of its rapid plasma membrane translocation on its activation loop …