[HTML][HTML] Expression of p53, Bax and Bcl-2 proteins in hepatocytes in non-alcoholic fatty liver disease
A Panasiuk, J Dzieciol, B Panasiuk… - World journal of …, 2006 - ncbi.nlm.nih.gov
A Panasiuk, J Dzieciol, B Panasiuk, D Prokopowicz
World journal of gastroenterology: WJG, 2006•ncbi.nlm.nih.govMETHODS: The expression of proapoptotic proteins p53, Bax, and antiapoptotic Bcl-2 in
hepatocytes with steatosis (SH) and without steatosis (NSH) was evaluated in 84 patients at
various stages of non-alcoholic fatty liver disease (NAFLD). RESULTS:
Immunohistochemical staining of liver tissue showed the activation of p53 protein in SH and
NSH with increased liver steatosis, diminished Bcl-2 and slightly decreased Bax protein.
Positive correlation was found between the stage of liver steatosis with p53 expression in …
hepatocytes with steatosis (SH) and without steatosis (NSH) was evaluated in 84 patients at
various stages of non-alcoholic fatty liver disease (NAFLD). RESULTS:
Immunohistochemical staining of liver tissue showed the activation of p53 protein in SH and
NSH with increased liver steatosis, diminished Bcl-2 and slightly decreased Bax protein.
Positive correlation was found between the stage of liver steatosis with p53 expression in …
METHODS: The expression of proapoptotic proteins p53, Bax, and antiapoptotic Bcl-2 in hepatocytes with steatosis (SH) and without steatosis (NSH) was evaluated in 84 patients at various stages of non-alcoholic fatty liver disease (NAFLD).
RESULTS: Immunohistochemical staining of liver tissue showed the activation of p53 protein in SH and NSH with increased liver steatosis, diminished Bcl-2 and slightly decreased Bax protein. Positive correlation was found between the stage of liver steatosis with p53 expression in SH (r= 0.54, P< 0.01) and NSH (r= 0.49, P< 0.01). The antiapoptotic protein Bcl-2 was diminished together with the advancement of liver steatosis, especially in non-steatosed hepatocytes (r= 0.43, P< 001).
CONCLUSION: Apoptosis is one of the most important mechanisms leading to hepatocyte elimination in NAFLD. The intensification of inflammation in NAFLD induces proapoptotic protein p53 with the inhibition of antiapoptotic Bcl-2.
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