Increased expression of connective tissue growth factor in fibrotic human liver and in activated hepatic stellate cells
EJ Williams, MDA Gaça, DR Brigstock, MJP Arthur… - Journal of …, 2000 - Elsevier
Background/Aims: Connective tissue growth factor is a recently described mitogenic protein
implicated in a variety of fibrotic disorders. Connective tissue growth factor may be a
downstream mediator of the pro-fibrotic and mitogenic actions of transforming growth factor-
β, promoting extracellular matrix deposition and fibrogenesis. As transforming growth factor-
β is considered important to the pathogenesis of hepatic fibrosis, we examined the possible
contribution of connective tissue growth factor to this process. Methods: Connective tissue …
implicated in a variety of fibrotic disorders. Connective tissue growth factor may be a
downstream mediator of the pro-fibrotic and mitogenic actions of transforming growth factor-
β, promoting extracellular matrix deposition and fibrogenesis. As transforming growth factor-
β is considered important to the pathogenesis of hepatic fibrosis, we examined the possible
contribution of connective tissue growth factor to this process. Methods: Connective tissue …