Antibody diversity: one enzyme to rule them all
MC Nussenzweig, FW Alt - Nature medicine, 2004 - nature.com
MC Nussenzweig, FW Alt
Nature medicine, 2004•nature.comThree reactions diversify antibody genes in human somatic cells of the B lineage: VDJ
recombination, somatic hypermutation and class-switch recombination. The discovery of
activation-induced cytidine deaminase (AID) has led to the elucidation of a unified molecular
mechanism for initiation of the last two reactions and suggests why B cells undergoing these
reactions are prone to cancer-associated DNA damage.
recombination, somatic hypermutation and class-switch recombination. The discovery of
activation-induced cytidine deaminase (AID) has led to the elucidation of a unified molecular
mechanism for initiation of the last two reactions and suggests why B cells undergoing these
reactions are prone to cancer-associated DNA damage.
Three reactions diversify antibody genes in human somatic cells of the B lineage: VDJ recombination, somatic hypermutation and class-switch recombination. The discovery of activation-induced cytidine deaminase (AID) has led to the elucidation of a unified molecular mechanism for initiation of the last two reactions and suggests why B cells undergoing these reactions are prone to cancer-associated DNA damage.
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