Memory B cells from older people express normal levels of cyclooxygenase-2 and produce higher levels of IL-6 and IL-10 upon in vitro activation
S Bancos, RP Phipps - Cellular immunology, 2010 - Elsevier
Worldwide the elderly population is increasing. The elderly show deficiencies in immune
function. B lymphocytes are essential elements of the immune system responsible for
antibody production. This laboratory previously showed that activated human B cells
isolated from young adults express cyclooxygenase-2 (Cox-2) and that Cox-2 is essential for
optimal antibody responses. Recent data suggests that Cox-2 expression decreases with
age in mouse bone tissue. There is no information regarding Cox-2 expression in B cells …
function. B lymphocytes are essential elements of the immune system responsible for
antibody production. This laboratory previously showed that activated human B cells
isolated from young adults express cyclooxygenase-2 (Cox-2) and that Cox-2 is essential for
optimal antibody responses. Recent data suggests that Cox-2 expression decreases with
age in mouse bone tissue. There is no information regarding Cox-2 expression in B cells …