Effects of aging on proliferation and E47 transcription factor activity induced by different stimuli in murine splenic B cells
D Frasca, D Nguyen, RL Riley, BB Blomberg - Mechanisms of ageing and …, 2003 - Elsevier
In the present paper, we have investigated the effects of aging on the expression and
function of the E2A-encoded transcription factor E47 in splenic B lymphocytes, unactivated
or activated with different stimuli (LPS, anti-CD40, anti-IgM, alone or in combination with IL-
4). Results indicate that unstimulated splenic B cells show very low E47 protein levels as
well as E47 DNA-binding activity and that, upon B cell activation, E47 expression and DNA-
binding activity are strongly induced in young and, to a significantly lesser extent, in old …
function of the E2A-encoded transcription factor E47 in splenic B lymphocytes, unactivated
or activated with different stimuli (LPS, anti-CD40, anti-IgM, alone or in combination with IL-
4). Results indicate that unstimulated splenic B cells show very low E47 protein levels as
well as E47 DNA-binding activity and that, upon B cell activation, E47 expression and DNA-
binding activity are strongly induced in young and, to a significantly lesser extent, in old …