[HTML][HTML] Matrix GLA protein modulates differentiation induced by bone morphogenetic protein-2 in C3H10T1/2 cells
K Bostrom, D Tsao, S Shen, Y Wang… - Journal of Biological …, 2001 - ASBMB
Matrix GLA protein (MGP) is ubiquitously expressed with high accumulation in bone and
cartilage, where it was found to associate with bone morphogenetic proteins (BMP) during
protein purification. To test whether MGP affects BMP-induced differentiation, three sets of
experiments were performed. First, pluripotent C3H10T1/2 cells transfected with human
MPG (hMGP) or antisense to hMGP (AS-hMGP) were treated with BMP-2. In cells
overexpressing hMGP, osteogenic and chondrogenic differentiation was inhibited indicating …
cartilage, where it was found to associate with bone morphogenetic proteins (BMP) during
protein purification. To test whether MGP affects BMP-induced differentiation, three sets of
experiments were performed. First, pluripotent C3H10T1/2 cells transfected with human
MPG (hMGP) or antisense to hMGP (AS-hMGP) were treated with BMP-2. In cells
overexpressing hMGP, osteogenic and chondrogenic differentiation was inhibited indicating …