[HTML][HTML] Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models
M Fujimoto, E Takaki, T Hayashi, Y Kitaura… - Journal of Biological …, 2005 - ASBMB
Polyglutamine diseases are inherited neurodegenerative diseases characterized by
misfolding and aggregation of proteins possessing expanded polyglutamine repeats. As
overexpression of some heat shock protein (Hsp) suppresses polyglutamine aggregates
and cell death, it is assumed that combined overexpression of Hsps will suppress that more
effectively. Here, we examined the impact of active forms of heat shock transcription factor 1
(HSF1), which induces a set of Hsps, on polyglutamine inclusion formation and disease …
misfolding and aggregation of proteins possessing expanded polyglutamine repeats. As
overexpression of some heat shock protein (Hsp) suppresses polyglutamine aggregates
and cell death, it is assumed that combined overexpression of Hsps will suppress that more
effectively. Here, we examined the impact of active forms of heat shock transcription factor 1
(HSF1), which induces a set of Hsps, on polyglutamine inclusion formation and disease …