Natural history in proximal spinal muscular atrophy: clinical analysis of 445 patients and suggestions for a modification of existing classifications
K Zerres, S Rudnik-Schöneborn - Archives of neurology, 1995 - jamanetwork.com
Objectives: To describe the natural history in all types of proximal spinal muscular atrophy
(SMA) and to propose a modified classification scheme that takes the longterm course of
SMA into account. Design: Patients with proximal SMA were studied prospectively and
retrospectively in a genetic study that was based on clinical and family data. Patients: Four
hundred forty-five patients with SMA were ascertained since 1985 through various
departments of neurology and neuropediatrics, institutes of human genetics, and the …
(SMA) and to propose a modified classification scheme that takes the longterm course of
SMA into account. Design: Patients with proximal SMA were studied prospectively and
retrospectively in a genetic study that was based on clinical and family data. Patients: Four
hundred forty-five patients with SMA were ascertained since 1985 through various
departments of neurology and neuropediatrics, institutes of human genetics, and the …