Ipsilateral and contralateral subthalamic activity after unilateral dopaminergic lesion
C Perier, Y Agid, EC Hirsch, J Feger - Neuroreport, 2000 - journals.lww.com
Unilateral lesions of the dopaminergic nigral neurons in rats are currently used as a model
of Parkinson's disease. However, several neurochemical studies have questioned the
possible influence of the lesioned side on the contralateral non-lesioned side. To address
this question, electrophysiological recordings in the ipsilateral and contralateral subthalamic
nucleus was performed on anaesthetized rats, 3, 7 and 14 days after induction of a unilateral
dopaminergic lesion. At these three times, the mean discharge rate of the subthalamic …
of Parkinson's disease. However, several neurochemical studies have questioned the
possible influence of the lesioned side on the contralateral non-lesioned side. To address
this question, electrophysiological recordings in the ipsilateral and contralateral subthalamic
nucleus was performed on anaesthetized rats, 3, 7 and 14 days after induction of a unilateral
dopaminergic lesion. At these three times, the mean discharge rate of the subthalamic …