A new centronuclear myopathy phenotype due to a novel dynamin 2 mutation

M Bitoun, JA Bevilacqua, B Eymard, B Prudhon… - Neurology, 2009 - AAN Enterprises
M Bitoun, JA Bevilacqua, B Eymard, B Prudhon, M Fardeau, P Guicheney, NB Romero
Neurology, 2009AAN Enterprises
Discussion. Although DVAs are considered to be relatively benign, there is growing
recognition that they may cause venous infarction or hemorrhage. Our patient demonstrates
that thrombosis of a DVA may occur in the hypercoagulable state induced by puerperium
and hormonal contraception, and possibly preeclampsia, which are risk factors for venous
sinus thrombosis. Management of this condition should include evaluation for inherited
thrombophilia and short-term anticoagulation. Given the relatively benign natural history of …
Discussion. Although DVAs are considered to be relatively benign, there is growing recognition that they may cause venous infarction or hemorrhage. Our patient demonstrates that thrombosis of a DVA may occur in the hypercoagulable state induced by puerperium and hormonal contraception, and possibly preeclampsia, which are risk factors for venous sinus thrombosis. Management of this condition should include evaluation for inherited thrombophilia and short-term anticoagulation. Given the relatively benign natural history of DVAs, the risks of hemorrhage during the course of short-term anticoagulation are expected to be minimal, while the benefits of anticoagulation for cerebral venous sinus thrombosis may be substantial. Surgical resection of a DVA is not recommended since the vessel may be the only venous drainage for the surrounding brain parenchyma. 1
American Academy of Neurology