[HTML][HTML] Src kinase activity is essential for osteoclast function
Deletion of the c-src gene impairs osteoclast bone resorbing activity, causing osteopetrosis.
Although it has been concluded that restoring only the Src adaptor function at least partly
rescues the cell attachment and skeletal phenotypes, the contribution of Src kinase activity
remains controversial. Src forms a complex with Pyk2 and Cbl after adhesion-induced
stimulation of α V β 3 integrin. To demonstrate the importance of the Pyk2-Src association in
osteoclasts and to distinguish the contributions of the Src adaptor and kinase activities in …
Although it has been concluded that restoring only the Src adaptor function at least partly
rescues the cell attachment and skeletal phenotypes, the contribution of Src kinase activity
remains controversial. Src forms a complex with Pyk2 and Cbl after adhesion-induced
stimulation of α V β 3 integrin. To demonstrate the importance of the Pyk2-Src association in
osteoclasts and to distinguish the contributions of the Src adaptor and kinase activities in …