Class II G protein-coupled receptors for VIP and PACAP: structure, models of activation and pharmacology

M Laburthe, A Couvineau, V Tan - Peptides, 2007 - Elsevier
VIP and PACAP impact strongly on human pathophysiology. Their receptors are very
promising targets for developing new drugs in the treatment of inflammatory and
neurodegenerative diseases. This article reviews the present knowledge regarding VIP and
PACAP receptors, ie VPAC1, VPAC2 and PAC1. This includes:(I) a critical review of
instrumental peptide agonists and antagonists;(II) a survey of recent data regarding the
structure of VPAC1 receptor and the docking of VIP in the receptor binding domain …